Which schedule has the lowest abuse potential among the listed schedules?

• A. Schedule I
• B. Schedule II
• C. Schedule III
• D. Schedule V

Answer: (D)

Abuse potential and medical usefulness are the keys here. Substances in the highest-risk category (with little or no accepted medical use) are placed in the most restricted schedule, while those with accepted medical uses and lower abuse risk move to less restrictive schedules. Among the options, Schedule V has the lowest abuse potential because it includes substances with only a small risk of dependence and is approved for legitimate medical use. The other schedules involve higher risks of abuse or less acceptable medical utility, so they don’t sit at the bottom of the risk spectrum.